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Aortic dissection (AD) is one of the serious diseases that threaten human life.Endovascular aortic ancurysm repair (EVAR),as a first-line treatment of type B AD,has the advantages of short operation time,little trauma,and rapid recovery.Previous studies have paid more attention to the clinical prognosis and imaging changes after endovascular repair of AD,with few focus on the quality of life after operation.The prevalence of coronary heart disease (CHD) has dramatically risen during the past few decades.Percutaneous coronary intervention (PCI) is considered one of the primary approaches for CHD treatment.Anxiety and depression are commonly associated with coronary heart disease (CHD).Psychological problems may be related with occurrence of unhealthy lifestyles and non-adherence to treatment.This study was to explore psychological characteristics and the quality of life and their influencing factors after interventional therapy of AD and CHD.Methods Respectively 100 AD and 100 CHD patients undergoing interventional therapy were investigated with SF-36,self-rating anxiety scale (SAS),self-rating depression scale (SDS)and social support scale.The values of SF-36,SAS,SDS between the AD and CHD group were analyzed.The influencing factors of quality of life were evaluated.Results There was no significant difference in SF-36 score between AD patients after endovascular repair and CHD patients after percutaneous coronary intervention.However,the scores in the dimensions of role-physical (54.00±41.54 vs.65.25±34.43,P=0.038) and social functioning (74.00±20.69 vs.81.00±20.35,P=0.020) were lower in AD patients than in CHD patients.Multiple linear regression analysis showed that age,occupational status,postoperative time,anxiety,depression,and social support were the influencing factors of life quality in aortic dissection patients.Conclusion Compared with CHD patients receiving percutaneous coronary intervention,quality of life in AD patients after endovascular repair should be paid attention to.It is necessary that a multidisciplinary team including psychological medical staff should be established to manage AD patients.