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造影剂是一种强有力的血管收缩剂,其血管收缩作用在注射后很快即可发生.高浓度造影剂对肾脏细胞有毒性作用,其毒性因低氧而加剧,在肾脏易于缺血缺氧的区域,如肾髓质,亨利氏襻升枝其毒性最大.动物试验证明,在肾功能正常,水化状态下,使用大剂量造影剂对肾脏无损伤,然而在一侧肾脏切除及钠耗竭情况下则产生毒性作用,消炎痛时增强其毒性作用.
Contrast agent is a potent vasoconstrictor whose vasoconstriction occurs very quickly after injection.High concentration of contrast agent has a toxic effect on kidney cells and its toxicity is exacerbated by hypoxia and is prone to ischemia in the kidney Oxygen regions, such as the medulla and Henrys ascending branch, have the highest toxicity.Animals tests have shown that in normal renal function, hydration, the use of large doses of contrast medium on the kidney without damage, however, in the side of the kidney and sodium Toxicity is produced by exhaustion, and its toxicity is enhanced by indomethacin.