[目的]在文山城区开展针对吸毒人群的艾滋病综合干预工作,促进同伴教育体系的建设及目标人群高危行为改变,并探索城市艾滋病性病综合干预模式。[方法]采用培训、同伴教育、发放宣传材料、观看录相、实施清洁针具交换等活动对目标人群进行综合干预。干预前后,利用《行为监测问卷》对吸毒人群进行艾滋病知识、态度和行为方面的调查。[结果]项目干预后,吸毒人群艾滋病知识知晓率提高达83.48%,共用注射器行为下降为14.2%,最近一次与非固定性伴性行为时安全套使用率提高到52.18%。[结论]在吸毒人群中开展艾滋病综合干预,可提高目标人群的艾滋病知识知晓率,降低和改变高危行为,有效遏制艾滋病在吸毒人群中的传播及蔓延。 [Objective] To carry out AIDS comprehensive intervention for drug addicts in Wenshan urban area, promote the construction of peer education system and high-risk behaviors of target population, and explore the integrated mode of AIDS STD intervention in urban areas. [Methods] The target population was comprehensively intervened by such activities as training, peer education, distributing publicity material, watching videos and implementing the exchange of clean needles. Before and after the intervention, using the “Behavior Monitoring Questionnaire” to survey the HIV / AIDS knowledge, attitude and behavior among drug users. [Results] After the intervention, the awareness rate of HIV / AIDS among drug addicts increased by 83.48%, that of shared syringes dropped to 14.2%, and the rate of condom use was 52.18% in the most recent non-regular sexual partners. [Conclusion] The HIV / AIDS comprehensive intervention among drug addicts can raise awareness rate of AIDS among target groups, reduce and change high-risk behaviors and effectively prevent the spread and spread of AIDS among drug users.