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在股部细菌性脓肿小鼠体内应用９９ｍＴｃ标记的柠檬酸进行显像和生物分布研究。在给药后短期内即可获得显示脓肿灶的满意图像。脓肿内放射性各时间均明显高于对侧未致炎肌肉，脓肿／肌肉放射性比值在１ｈ即达４．５５±０．５３。脓肿／血液比值逐渐升高，２４ｈ达１．５０±０．２４。而同期肌肉内放射性均明显低于血液水平。９９ｍＴｃ柠檬酸经肾排泄迅速。结果表明，９９ｍＴｃ－柠檬酸是一种简单有效的炎症显像剂。
99mTc-labeled citric acid was used for imaging and biodistribution studies in femoral bacterial abscess mice. Satisfactory images showing abscesses can be obtained shortly after administration. Abscess within the radioactivity were significantly higher than the contralateral side of the inflammation-free muscle, abscess / muscle radioactivity ratio reached 4.55 ± 0.53 at 1h. Abscess / blood ratio increased gradually, reaching 1.50 ± 0.24 at 24h. The same period, intramuscular radioactivity were significantly lower than the blood level. 99mTc citrate rapidly excreted by the kidneys. The results show that 99mTc-citric acid is a simple and effective inflammatory imaging agent.