DNA错配修复基因SNPs是个体间DNA错配修复能力差异的主要原因,是决定机体肿瘤易感的一个重要因素。当前,关于DNA错配修复系统基因SNPs与大肠癌易感性方面的研究,涉及到的基因还不够全面,尚无法明确二者关系。随着高通量SNPs筛查技术的进步,并充分考虑多基因遗传、环境、种族等因素的情况下,才能建立起基因SNPs与大肠癌易感性之间较为明确的关联,为大肠癌的早诊、预防及治疗提供依据。 DNA mismatch repair gene SNPs is the main reason for the differences in DNA mismatch repair ability between individuals and is an important factor in determining the susceptibility of the tumor to the body. At present, the research on DNA mismatch repair system gene SNPs and colorectal cancer susceptibility, the genes involved are not comprehensive enough, it is not clear the relationship between the two. With the progress of high-throughput SNPs screening technology, and taking full account of multiple genetic, environmental, ethnic and other factors in order to establish a more clear association between gene SNPs and susceptibility to colorectal cancer, colorectal cancer early Diagnosis, prevention and treatment to provide the basis.