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目的观察替比夫定联合复方鳖甲软肝片对慢性乙型病毒性肝炎(乙肝)患者肝功能的影响及对肝纤维化预防作用。方法将慢性乙肝患者110例根据随机数字表法分为观察组与对照组各55例。对照组给予替比夫定治疗,观察组在对照组基础上联合鳖甲软肝片治疗,观察2组患者肝功能指标变化、肝纤维化水平。结果治疗前2组患者肝功能指标水平比较差异无统计学意义(P>0.05);治疗后2组患者总胆红素和丙氨酸氨基转移酶水平均低于治疗前,白蛋白水平高于治疗前,且观察组肝功能指标变化幅度大于对照组,差异具有统计学意义(P<0.05)。治疗前2组患者肝纤维化水平差异不显著(P>0.05),治疗后2组患者血清透明质酸、层黏连蛋白、Ⅵ型胶原水平均低于治疗前,且观察组患者的肝纤维化水平低于对照组,差异均有统计学意义(P<0.05)。结论替比夫定联合复方鳖甲软肝片治疗慢性乙型病毒性肝炎患者临床效果显著,可明显改善患者肝功能,并对肝纤维化有确切预防作用,值得临床推广应用。
Objective To observe the effects of telbivudine and Fufang Biejia Ruangan Tablet on liver function in patients with chronic hepatitis B (hepatitis B) and its preventive effect on hepatic fibrosis. Methods One hundred and ten patients with chronic hepatitis B were divided into observation group and control group according to random number table method. The control group was treated with telbivudine. The observation group was treated with Biejia Ruangan Pian on the basis of the control group. The changes of liver function index and liver fibrosis were observed in the two groups. Results There was no significant difference in the level of liver function between the two groups before treatment (P> 0.05). The levels of total bilirubin and alanine aminotransferase in two groups after treatment were lower than those before treatment Before treatment, the changes of liver function indexes in the observation group were greater than those in the control group, with significant difference (P <0.05). There was no significant difference in the level of liver fibrosis between the two groups before treatment (P> 0.05). The levels of serum hyaluronic acid, laminin and type Ⅵ collagen in the two groups after treatment were lower than those before treatment, and liver fibrosis The levels were lower than the control group, the differences were statistically significant (P <0.05). Conclusion The effect of telbivudine and Fufang Biejia Ruangan Tablet in the treatment of patients with chronic hepatitis B is significant. It can significantly improve the liver function of patients and has an exact preventive effect on liver fibrosis. It is worthy of clinical application.