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应用放免法对118例胃癌术前病人血清AFP进行检测,发现AFP水平与肝转移、淋巴转移呈明显的正相关。AFP阳性胃癌的病理类型主要为高分化的乳头状或管状腺癌及低分化的髓样癌,这种低分化的髓样癌癌细胞类似于原发性肝癌细胞。AFP阳性组肝转移率为60％,明显高于AFP阴性组的6.5％。从淋巴结转移距离及转移个数上看,N_2组AFP阳性率明显高于N_0、N_1组,多个转移组明显高于无转移组及少数转移组。本研究表明,术前检测血清AFP对判定病期的早晚、合理地制定治疗方案及估计预后有重要意义。
Using radioimmunoassay to detect serum AFP in 118 preoperative patients with gastric cancer, it was found that AFP levels were positively correlated with liver metastasis and lymphatic metastasis. The pathological types of AFP-positive gastric cancer are mainly well-differentiated papillary or tubular adenocarcinoma and poorly differentiated medullary carcinoma. This poorly differentiated medullary carcinoma cell is similar to primary hepatocellular carcinoma. The liver metastasis rate in AFP-positive group was 60%, which was significantly higher than 6.5% in AFP-negative group. From the perspective of lymph node metastasis distance and number of metastases, the positive rate of AFP in N2 group was significantly higher than that in N_0, N_1 group. The number of metastasis group was significantly higher than that of non-metastasis group and minority metastasis group. This study shows that the preoperative detection of serum AFP is of great significance in determining the time of the disease, establishing a reasonable treatment plan and estimating the prognosis.