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晚期糖化终末产物受体(receptor for advanced glycation end product,RAGE)是一种单穿膜受体,同时也是一种多配体受体,属于免疫球蛋白超家族的成员。其配体包括高速泳动族框1蛋白质(high mobility group box 1,HMGB1)、晚期糖化终末产物(advanced glycation end product,AGE)、S100/钙粒蛋白(calgranulin)及β淀粉样肽等。在肝脏中,RAGE主要表达于巨噬细胞与树突状细胞上。RAGE一旦被激活,就会通过一系列的信号传导,诱导这些细胞释放出多种促炎症的物质,并引起中性粒细胞沉积,产生瀑布式的炎症反应链。肝脏的缺血再灌注(ischemia/reperfusion,I/R)损伤作用机制繁多。其中RAGE作为一个关键的调节点,各种外来和内在的因素都可以通过作用于RAGE从而影响炎症反应。现就肝脏I/R损伤与RAGE之间关系做一综述。
The receptor for advanced glycation end product (RAGE) is a single transmembrane receptor that is also a multi-ligand receptor and belongs to the immunoglobulin superfamily. Its ligands include high mobility group box 1 (HMGB1), advanced glycation end product (AGE), S100 / calgranulin and amyloid beta peptide. In the liver, RAGE is mainly expressed on macrophages and dendritic cells. Once activated, RAGE, through a series of signaling pathways, induces these cells to release a variety of proinflammatory substances and cause neutrophil deposition, creating a cascade of inflammatory reactions. Liver ischemia / reperfusion (I / R) injury mechanism of action. Which RAGE as a key regulatory point, a variety of external and internal factors can affect the inflammatory response by acting on RAGE. Now the relationship between liver I / R injury and RAGE is reviewed.