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报告2例SLE患者发生急性播散性非炎症性内脏血管闭塞,同时有高滴度的抗磷脂抗体(aPL)。组织病理改变与典型的SLE血管炎明显不同。根据可能与存在aPL相关的发病机理,以及非炎症性血管闭塞,故类固醇和其他免疫抑制剂的疗效甚微,而应考虑使用血浆置换术和抗凝治疗。例1.女,37岁。因肢端进行性疼痛和出现缺血性改变就诊。患者有SLE病史20年,但健康状况良好且不需皮质激素治疗,入院前数月几个指趾发生固定性青紫且手指
Two cases of SLE were reported to have acute disseminated non-inflammatory visceral vasoconstriction with a high titer of anti-phospholipid antibody (aPL). Histopathological changes and the typical SLE vasculitis significantly different. Steroids and other immunosuppressive agents have little effect based on the pathogenesis that may be associated with the presence of aPL, as well as noninflammatory vascular occlusion, but plasmapheresis and anticoagulation should be considered. Example 1. Female, 37 years old. Due to extremity pain and ischemic changes. Patients had a history of SLE for 20 years but were in good health and did not require corticosteroid treatment. Fixed digitized fingers