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目的：考察聚氯乙烯（ＰＶＣ）软袋装川芎嗪在腹膜透析液中的稳定性。方法：含川芎嗪０．０４ｍｇ·ｍｌ－１和０．２０ｍｇ·ｍｌ－１的腹膜透析液分别置于４℃，２５℃和３７℃，定时取样以ＨＰＬＣ测定含量，药物浓度降低≤５％为稳定性指标。结果：由于ＰＶＣ软袋的吸附作用，各浓度在２５℃６ｈ后均有显著性降低，１２ｈ后降至９５％以下；３７℃４ｈ即均有显著性降低，８ｈ后降至９５％以下。０．２０ｍｇ·ｍｌ－１（４℃）在２４ｈ后浓度明显下降，但１０ｄ后浓度下降未超过５％，０．０４ｍｇ·ｍｌ－１（４℃）在观察期间浓度略有升高。结论：ＰＶＣ软袋可吸附川芎嗪，随温度的升高，吸附作用亦增强。川芎嗪溶于腹膜透析液后室温贮放不宜超过６ｈ，温度升至３７℃后尽快使用。
Objective: To investigate the stability of ligustrazine in PVC peritoneal dialysis solution. Methods: Peritoneal dialysate containing ligustrazine 0.04mg · ml-1 and 0.20mg · ml-1 were placed in 4 ℃, 25 ℃ and 37 ℃, respectively. The content of the drug was reduced by 5% Stability indicators. Results: Due to the adsorption of PVC pouch, all the concentrations were significantly decreased after 6 hours at 25 ° C, and dropped below 95% after 12 hours; at 37 ° C for 4 hours, all of them were significantly reduced and dropped below 95% after 8 hours. The concentration of 0.20mg · ml-1 (4 ℃) decreased obviously after 24h, but the concentration did not drop more than 5% after 10d. The concentration of 0.04mg · ml-1 (4 ℃) slightly increased during the observation period. CONCLUSION: Tetramethylpyrazine can be absorbed by PVC soft bag. With the increase of temperature, the adsorption is also enhanced. Tetramethylpyrazine dissolved in peritoneal dialysis fluid should not be stored at room temperature more than 6h, the temperature rose to 37 ℃ as soon as possible after use.