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目的 :研究急性脑硬死患者血清神经元特异性烯醇化酶 (NSE)和谷胱甘肽 -S -转移酶 (GST)的变化及其临床意义。方法 :应用免疫放射分析 (IRMA)法测定血清NSE含量和应用酶联免疫反应 (ELISA)法测定血清GST含量。结果 :脑梗死患者发病 3天内血清NSE含量高于对照组和 2周时 (p <0 0 1) ,血清GST含量低于对照组和 2周时 (p<0 0 1)。血清NSE含量与神经功能缺损程度呈正相关 (p <0 0 0 1) ,与血清GST含量呈负相关 (p <0 0 5 ) ,也与梗死灶体积有关 (p <0 0 0 1)。结论 :急性脑梗死患者早期血清NSE和GST的水平变化与脑梗死的临床表现关系密切
Objective: To investigate the changes and clinical significance of serum neuron specific enolase (NSE) and glutathione S-transferase (GST) in patients with acute brain injury. Methods: Serum NSE levels were determined by immuno-radiometric analysis (IRMA) and serum GST levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Serum NSE levels in patients with cerebral infarction within 3 days after onset were higher than those in the control group and at 2 weeks (p <0.01), serum GST levels were lower than those in the control group and at 2 weeks (p <0.01). Serum NSE levels were positively correlated with the degree of neurological deficits (p <0.01), negatively correlated with serum GST levels (p <0.05), and also with infarct volume (p <0.001). Conclusion: The changes of serum NSE and GST levels in patients with acute cerebral infarction are closely related to the clinical manifestations of cerebral infarction