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目的:总结188例患者采用利培酮、氯氮平、喹硫平等精神类药品后出现的毒副反应。方法:收集我院因服用精神类药品出现毒副反应的患者188例,统计药品种类、毒副反应器官、疾病类型。结果:入选的188例患者中,男性患者为138例,女性患者为50例,男性比例高于女性(73.4%比26.6%,P<0.05)。精神疾病类型中精神分裂症比例最高(52.1%),和其他疾病种类比较均有显著差异(P<0.05)。神经系统毒副反应发生率最高(44.7%),与其他系统或器官毒副反应发生率比较有显著差异(P<0.05)。精神类药品中利培酮毒副作用最大,涉及的系统或器官最多。结论:精神类药品毒副反应多,可影响到神经系统、内分泌系统等多个系统及器官。临床中应用精神类药品时应加强监测,并尽量使用毒副作用影响较小的药物进行治疗。
OBJECTIVE: To summarize the toxic side effects of 188 patients taking risperidone, clozapine, quetiapine and other psychotropic drugs. Methods: A total of 188 patients with side effects of taking psychotropic drugs in our hospital were collected. The types of drugs, toxic and side reaction organs, and types of diseases were collected. Results: Of the 188 patients enrolled, 138 were male and 50 were female, with a higher proportion of males than females (73.4% vs. 26.6%, P <0.05). The highest prevalence of schizophrenia (52.1%) was in the mental illness category, which was significantly different from other diseases (P <0.05). The highest incidence of nervous system toxicity (44.7%), and other systems or organ toxicity was significantly different (P <0.05). Risperidone drugs in the spirit of the largest side effects, involving the most systems or organs. Conclusion: The psychotropic drugs have many side effects and can affect many systems and organs such as nervous system and endocrine system. Clinical application of psychotropic drugs should be strengthened monitoring, and try to use less toxic side effects of drugs for treatment.