ｐ５３基因是人类进化上的高度保守基因，有５个高度保守区，其间的一个密码子突变可导致肿瘤的发生［１］。近年来，国内外对ｐ５３基因有过较多研究［２］，认为ｐ５３基因突变在恶性肿瘤中较普遍［３］，但国内用测序方法研究ｐ５３基因不多。为了解胃粘膜腺癌与ｐ５３基因 The p53 gene is a highly conserved gene in human evolution. There are five highly conserved regions, and a mutation in one of the p53 genes can lead to tumorigenesis [1]. In recent years, there have been more studies on the p53 gene at home and abroad [2]. It is considered that p53 gene mutations are more common in malignant tumors [3]. However, few p53 genes have been studied using sequencing methods in China. To understand gastric adenocarcinoma and p53 gene