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对肝脏疾病的应用:Rausch氏认为肝性昏迷系丙酮酸氧化不全,则血中丙酮酸含量上升的结果,而硫辛酸为丙酮酸氧化必要的辅酶,因此降低血中氧化不全丙酮酸含量,故可用于肝性昏迷。一、对肝炎肝硬化的治疗:Rausch曾用于急性及慢性肝炎及肝硬化等57例,每日硫辛酸1.1—6.6mg静脉注射,自觉症状31例有显著疗效,18例有效,8例无效。疲劳感,晕眩,食欲不振,睡眠障碍等最初注射后2—36时后上述症状略微消失。对慢性肝炎的治疗可改善病情,结果血清白蛋白增加,γ-球蛋白含量降低,以四溴酚酜钠试肝功能改
The application of liver disease: Rausch’s view that hepatic coma pyruvate oxidative insufficiency, the blood pyruvate increased the results, and lipoic acid is the necessary coenzyme for pyruvate oxidation, thus reducing blood pyruvate levels, so it Can be used for hepatic coma. First, the treatment of hepatitis cirrhosis: Rausch was used in 57 cases of acute and chronic hepatitis and cirrhosis, daily lipoic acid 1.1-6.6mg intravenously, 31 cases of symptoms have a significant effect, 18 cases were effective, 8 cases were ineffective . Fatigue, dizziness, loss of appetite, sleep disorders such as 2-36 after the initial injection of the above symptoms disappeared slightly. Treatment of chronic hepatitis can improve the condition, the results of serum albumin increased, γ-globulin content decreased to tetrabromophenol sodium test liver function changes