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环氧司坦(epostane,Epo)为3β-羟甾脱氢酶抑制剂,在口服96mg/kg的剂量下,可使大鼠终止妊娠,血浆孕酮水平下降。肌肉注射hCG(150 IU/鼠)不能拮抗Epo的止孕作用。光镜下发现Epo使妊娠大鼠的子宫内膜增殖、弯曲,上皮呈假复层,核分裂;大部分黄体细胞核固缩或消失,细胞质出现空泡。大鼠于妊娠d 10口服Epo后,电镜下发现d 12时黄体细胞排列不规则,细胞间隙增宽,脂滴增多,电子密度下降;d 16时滑面内质网减少。结果表明Fpo作用于黄体,其溶黄体作用可能是Epo止孕作用的原因之一。
Epostane (Epos) is a 3β-hydroxysteroid dehydrogenase inhibitor, which can induce termination of pregnancy and a decrease in plasma progesterone level at an oral dose of 96 mg / kg. Intramuscular injection of hCG (150 IU / mouse) failed to antagonize the antiemetic effect of Epo. Under light microscope, Epo was found to proliferate and bend the endometrium of pregnant rats. The epithelium was pseudostratified and mitotic. Most of the corpus luteum nuclei were pyknotic or disappeared, and cytoplasm vacuolization occurred. After oral administration of Epo on day 10 of gestation, the luteal cells arranged irregularly on d 12 under electron microscope. The interstitial spaces widened, lipid droplets increased and the electron density decreased. At d 16, the endoplasmic reticulum decreased. The results showed that Fpo role in the corpus luteum, the role of the corpus luteum may be one of the reasons for the role of Epo only.