Type 2 diabetes mellitus (T2DM) is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin, accounts for 90％ of diabetes and causes a range of complications[1].It has been suggested that inflammation contributed to the pathogenesis of T2DM, which may result in severe insulin resistance (IR)[2].Liver plays a pivotal role in glucolipid metabolism as hepatic glycogen is synthesized and stored within the organ[3].