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目的:观察5-氨基酮戊酸(ALA)光动力疗法治疗头面部日光性角化、鲍温氏病、浅表基底细胞癌的临床疗效及不良反应。方法:头面部皮肤恶性肿瘤及癌前病变患者32例42个皮损,接受5-氨基酮戊酸光动力疗法治疗,所有病例均经过组织病理学检查确诊。其中日光性角化病13例,鲍温氏病8例,浅表基底细胞癌11例。治疗每周1次,采用20%ALA溶液外敷3h后红光照射,输出波长630 nm,能量密度100 J/cm~2。治疗3~5次后进行疗效判定。疗效判断采用Dougherty报道的标准:完全反应(CR)为病变皮损全部消失,部分
Objective: To observe the clinical efficacy and adverse reactions of 5-aminolevulinic acid (ALA) photodynamic therapy in the treatment of solar keratosis, Bowen’s disease and superficial basal cell carcinoma of head and face. Methods: Thirty-two lesions in 32 patients with head and facial skin cancer and precancerous lesions were treated with 5-aminolevulinic acid photodynamic therapy. All cases were confirmed by histopathological examination. Including solar keratosis in 13 cases, Bowen’s disease in 8 cases, superficial basal cell carcinoma in 11 cases. Treatment once a week, with 20% ALA solution 3h after the red light irradiation, the output wavelength of 630 nm, the energy density of 100 J / cm ~ 2. Treatment 3 to 5 times after the efficacy of judgment. The curative effect was evaluated using the standard reported by Dougherty: complete response (CR) was complete disappearance of lesions lesions, part