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研究亚硒酸钠（Ｎａ_２ＳｅＯ_３）和丝裂霉素（ＭＭＣ）、盐酸阿霉素（ＡＤＭ）对ＱＧＹ—７７０３人肝癌细胞生长的影响。结果表明：终浓度为１μｇ／ｍｌ的Ｎａ２ＳｅＯ３，可明显抑制肝癌细胞的生长增殖、减少细胞对甲胎蛋白（ＡＦＰ）的分泌；１μｇ／ｍｌ的Ｎａ２Ｓｅ０３与１．５μｇ／ｍｌ的ＭＭＣ或１５μｇ／ｍｌ的ＡＤＭ联合应用对肝癌细胞生长增殖的抑制作用，不论是细胞生长的抑制率、还是肝癌细胞分泌ＡＦＰ的抑制率，均明显高于各自的单独应用效果，差异有显著性意义（Ｐ＜０．０５）．并随着培养时间的延长、抑制程度持续增强。提示Ｎａ_２ＳｅＯ_３与抗癌药联合应用。具有良好的协同或相加抑癌、抗癌效应。对临床应用有一定的实际意义。
To study the effects of sodium selenite (Na_2SeO_3), mitomycin C (MMC) and doxorubicin hydrochloride (ADM) on the growth of QGY-7703 human hepatoma cells. The results showed that Na2SeO3 at a final concentration of 1μg / ml could significantly inhibit the growth and proliferation of hepatocellular carcinoma cells and reduce the secretion of AFP; 1μg / ml Na2Se03 and 1.5μg / ml MMC or 15μg / ml ADM combined with ADM could inhibit the growth and proliferation of hepatocarcinoma cells both in the inhibition of cell growth and in the secretion of AFP by hepatocarcinoma cells, which were significantly higher than those of single application (P <0. 05). And with the extension of incubation time, the degree of inhibition continued to increase. Prompt Na_2SeO_3 combined with anti-cancer drugs. Has a good synergistic or additive tumor suppressor, anti-cancer effect. The clinical application of a certain practical significance.