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目的 :了解干扰素对口腔粘膜分泌SIgA的调节作用。方法 :以生物素 -ELISA法检测口腔使用干扰素前后小鼠唾液SIgA的水平。结果 :大、小剂量干扰素组在用药后 10天、2 0天和 3 0天都能增高唾液SIgA ,并同对照组相比有显著差异 (P <0 0 5 ) ;大剂量组SIgA的增高更多 ,特别是在 2 0天时明显高于小剂量组 (P <0 0 5 ) ;干扰素的调节作用持续至少 3 0天 ,小剂量在维持作用方面不亚于大剂量。结论 :干扰素直接作用于口腔粘膜 ,可提高局部的SIgA的分泌水平。
Objective: To understand the regulatory effect of interferon on SIgA secretion in oral mucosa. Methods: The level of SIgA in saliva before and after oral administration of interferon was detected by biotin-ELISA. Results: The SIgA of saliva was increased in the large and small interferon groups at 10 days, 20 days and 30 days after treatment, which was significantly different from the control group (P <0 05). The SIgA (P <0 05). The regulation effect of interferon lasted at least 30 days, and the small dose was no less than the high dose in maintenance effect. Conclusion: The direct effect of interferon on oral mucosa can increase the level of local SIgA secretion.