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目的观察垂体后叶素联合酚妥拉明治疗支气管扩张并大咯血的临床疗效。方法选取2013年6月—2016年3月南通市通州区人民医院呼吸内科收治的支气管扩张并大咯血患者50例,采用硬币投掷法分为对照组和观察组,每组25例。两组患者入院后均给予抗感染、镇静、止咳及吸氧等常规治疗,对照组患者在常规治疗基础上给予垂体后叶素静脉滴注,观察组患者在常规治疗基础上给予垂体后叶素联合酚妥拉明静脉滴注。比较两组患者临床疗效、咯血时间、总咯血量及不良反应发生率。结果观察组患者临床疗效优于对照组(P<0.05)。观察组患者咯血时间短于对照组,总咯血量低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论垂体后叶素联合酚妥拉明治疗支气管扩张并大咯血的临床疗效优于单用垂体后叶素,可有效缩短咯血时间、降低总咯血量,且不良反应发生率较低。
Objective To observe the clinical efficacy of vasopressin combined with phentolamine in the treatment of bronchiectasis and hemoptysis. Methods Fifty patients with bronchiectasis and hemoptysis admitted to Department of Respiratory Medicine, Tongzhou District People’s Hospital, Nantong City from June 2013 to March 2016 were divided into control group and observation group with coin throwing method, 25 cases in each group. Two groups of patients were given anti-infective, sedative, cough and oxygen and other conventional treatment after admission, the control group patients were given pituitrin intravenous drip on the basis of conventional treatment, the observation group patients were given pituitrin on the basis of routine treatment Phentolamine combined intravenous infusion. The clinical efficacy, hemoptysis time, total hemoptysis and incidence of adverse reactions in the two groups were compared. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). The hemoptysis time in the observation group was shorter than that in the control group, and the total hemoptysis volume was lower than that in the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The clinical efficacy of pituitrin and phentolamine in treating bronchiectasis and hemoptysis is superior to that of pituitrin alone. It can shorten the time of hemoptysis and reduce the total hemoptysis, and the incidence of adverse reactions is low.