目的　探讨抗氧化剂联合接触镜治疗圆锥角膜急性水肿期的治疗效果。方法　 16例 (18只眼 )采用抗氧化剂 :2 %谷胱甘肽滴眼液局部点眼。口服维生素 C、维生素 E。为减轻水肿及炎症反应 ,局部加点 4%氯化钠滴眼液 ,0 .1%双氯灭痛滴眼液。防止合并感染用 0 .3%环丙沙星滴眼液局部点眼。经药物治疗水肿减轻 ,能耐受接触镜 ,可戴接触镜进行光学矫正。分别选戴 RGPCL 16只眼 ,Piggyback lens2只眼 ,定期复查。结果　 18只眼圆锥角膜急性水肿期经治疗后 3～ 5周水肿基本消退。瘢痕形成 ,呈半透明 ,角膜锥顶逐渐扁平化。偏离视轴区瘢痕矫正视力良好 ,视力矫正结果 0 .5～ 0 .8者占 11只眼 (其中 0 .8以上 4只眼 )占 6 1%。 0 .5以下～ 0 .1者 5只眼。 0 .0 5者 2只眼 ,占 11%。经观察全部病例 ,无并发症 ,角膜散光及近视度逐渐减少 ,角膜曲率半径逐渐增大 ,角膜地形图显示SRI、SAI值逐渐减少 ,逐渐向角膜表面规则和球面性转化。结论　谷胱甘肽、维生素 C、E均属于抗氧化药物。对于圆锥角膜急性水肿期减轻水肿 ,愈合后弹力层裂孔起到有效的积极治疗作用。接触镜有较好的矫形作用 ,对控制病情发展有一定的治疗作用。此方法具有见效快 ,疗效可靠 ,容易操作 ,具有安全性高的优越性 Objective To investigate the therapeutic effect of anti-oxidant combined with contact lens in the treatment of keratoconus acute edema. Methods 16 cases (18 eyes) with anti-oxidant: 2% glutathione eye drops local eye. Oral vitamin C, vitamin E. In order to reduce edema and inflammatory response, add 4% sodium chloride eye drops locally, 0.1% diclofenac eye drops. Prevent co-infection with 0.3% ciprofloxacin eye drops local eye. Edema relieved by drug treatment, can tolerate contact lenses, contact lenses can be worn for optical correction. Were selected RGPCL 16 eyes, Piggyback lens2 eyes, regular review. Results Eighteen eyelid edema subsided 3 to 5 weeks after eyelid edema in 18 eyes. Scar formation, was translucent, corneal top cone gradually flattened. Deviations from the visual field of the scar corrected visual acuity, visual acuity results 0.5 ~ 0.8 people accounted for 11 eyes (of which 0.8 above 4 eyes) accounted for 6 1%. 0 .5 or less ~ 0 .1 5 eyes. 0 .0 5 2 eyes, accounting for 11%. All cases were observed, no complications, corneal astigmatism and myopia decreased gradually, the corneal curvature radius gradually increased, corneal topography showed SRI, SAI value gradually decreased gradually to the corneal surface of the rules and spherical transformation. Conclusion Glutathione, vitamin C and E are all anti-oxidants. For acute edema of keratoconus to reduce edema, elastic layer after healing crack played an active and effective treatment. Contact lenses have a good orthopedic effect on the control of disease development has a certain therapeutic effect. This method is effective, reliable, easy to operate, with high safety superiority