致病性大腸杆菌是中毒性消化不良症的重要病原,但对发病机制及病变情况还不很清楚,我們将小白鼠20只、豚鼠8只、家兔8只分为四組,第一組給予由北京儿研所培养O_(111)B_4型菌株(簡称北組);第二組給予由病儿尹××分离O_(111)B_4型菌株(簡称尹組);第三組給予由病儿王××分离O_(111)B_4型菌株(簡称王組);第四組給予普通大腸杆菌(簡称普組)以作对照。上述菌株均經生化血清反复鉴定,希望从动物实驗結果、結合临床,探討病变及发病机制。 (一)动物实驗結果甲、小白鼠实驗: 方法:用乳鼠20只体重10-15克分为四組,第一組北組5只;第二組尹組5只;第三組王組5只;第四組普組5只,将活菌15亿作腹腔注射,注射后24小 Pathogenic Escherichia coli is an important pathogen of toxic dyspepsia, but the pathogenesis and pathological conditions are not yet clear, we will 20 mice, 8 guinea pigs, 8 rabbits were divided into four groups, the first group (111) B_4 type strain (abbreviated as Yin group) were isolated from Yin × × in the second group, and the third group The O_ (111) B_4 type strain (referred to as the king group) was isolated from the sick child Wang × ×; the fourth group was given ordinary E. coli (abbreviated as Pu group) for comparison. The above strains were repeatedly identified by biochemical serum, hoping from the animal experimental results, combined with clinical, explore the pathogenesis and pathogenesis. (A) Animal experiment results A, mice experiments: Methods: 20 rats weighing 10-15 grams divided into four groups, the first group of the North Group 5; the second group Yin group 5; the third group of Wang group 5; the fourth group of general group of 5, 1.5 billion live viable for intraperitoneal injection, 24 hours after injection