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绝经后妇女冠心病发病率急剧上升,这主要是由于绝经后内源性雌激素水平低下所致[1]。雌激素替代疗法(HRT)可改善围绝经期妇女生活质量、降低冠心病发生率,然而,HRT可能导致生殖系统肿瘤、乳腺癌、子宫内膜增生等则影响了其应用。因此,能对心血管系统等有保护作用,且无不良影响的植物雌激素(phytoestrogen,PE)成为防治绝经期妇女冠心病的最好药物。
The prevalence of coronary heart disease in postmenopausal women has risen sharply, mainly due to the low levels of endogenous estrogens in the postmenopausal period [1]. Estrogen replacement therapy (HRT) can improve perimenopausal women’s quality of life and reduce the incidence of coronary heart disease, however, HRT may lead to reproductive system cancer, breast cancer, endometrial hyperplasia, etc. affect its application. Therefore, phytoestrogen (PE), which has a protective effect on the cardiovascular system and the like, has no adverse effect as the best medicine for preventing and treating coronary heart disease in postmenopausal women.