本文报告了3例因缺乏葡糖-6-磷酸脱氢酶,在应用氯喹治疗疟疾时,引起血管内溶血而导致急性肾功能衰竭。 (一)病史 3例患者均为男孩,年龄依次为7.5、11及10岁。入院前均发热或伴有发冷,在确诊为疟疾后应用氯喹治疗,剂量为150～300毫克,服药后均出现呕吐、并排出黑色或咖啡色小便,其中例2及例3则发展为尿闭或尿少。(二)体检3例均面色苍白, This article reports three cases of acute renal failure resulting from intravascular hemolysis caused by the lack of glucose-6-phosphate dehydrogenase in the treatment of malaria with chloroquine. (A) the history of 3 patients were boys, followed by the age of 7.5,11 and 10 years of age. Before admission to patients with fever or chills, in the diagnosis of malaria after the application of chloroquine therapy, a dose of 150 to 300 mg, were vomiting after taking medication and excretion of black or brown urine, of which cases 2 and 3 developed into the urine closed Or oliguria. (B) Physical examination 3 cases were pale,