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药物靶点的研究一直是新药研发中最重要的内容之一,microRNA(miRNA)作为调节基因与蛋白之间相互关系的纽带无疑是药物靶点研究的重要对象,以它们作为靶点的药物设计和药物研发工作也在不断深入,并获得了一系列新发现.其中,对细胞内miRNA的表达或者功能具有调控活性的化学小分子的研究很值得关注.这些化学小分子不但可以用于研究细胞内miRNA的调控网络,而且基于其对重大疾病,如肿瘤、心脏疾病、神经性疾病等相关的miRNA的调控,可能在将来的疾病治疗方面有着潜在的重要作用.本文围绕miRNA化学小分子抑制剂及其筛选方法进行综述,通过总结归纳现有的研究进展,希望对今后的miRNA特异性小分子抑制剂的发现和研究提供借鉴.
Drug target research has always been one of the most important parts in the research and development of new drugs. As a link between gene and protein, microRNA (miRNA) is undoubtedly an important target of drug target research, and the drug design targeting them And drug research and development are also in-depth, and made a series of new discoveries.Among them, the study of the expression of small cells or miRNAs with regulatory activity of small molecules is of great concern.These small chemical molecules not only can be used to study cells Regulation of miRNAs and its regulation of miRNAs related to major diseases such as cancer, heart disease and neurological diseases may play a potentially important role in future disease treatment.In this paper, miRNA chemical small molecule inhibitors This review summarizes the current research progress and hopes to provide references for the future discovery and study of miRNA-specific small molecule inhibitors.