论文部分内容阅读
HBV及类似的动物DNA病毒属嗜肝病毒,即病毒的复制和所引起的细胞损害主要限于肝脏。然而,最近的研究提示,HBV可以在肝细胞以外的组织中复制,但肝外复制的意义尚未阐明。哺乳动物和鸟类嗜肝病毒的发现为体内研究HBV感染提供了优良而经济的模型。在肝外嗜肝病毒复制的最初报道之后,又有许多有关病毒感染部位的研究。Hal-pern等发现在感染鸭的胰和肾中有鸭乙型肝炎病毒(DHBV)DNA的复制中间体,即聚腺苷酸化DHBV RNA和病毒抗原。复制中间体的存在提示,DNA并不是因血源污染所致,而是细胞内活跃复制产生。聚腺
HBV and similar animals The DNA virus is an hepadnavirus, ie the replication of the virus and the cell damage caused are mainly confined to the liver. However, recent studies suggest that HBV can replicate in tissues other than hepatocytes, but the significance of extrahepatic replication has not been elucidated. The discovery of mammalian and avian hepatotropic viruses provides an excellent and economical model for studying HBV infection in vivo. After the initial report of extrahepatic hepadnavirus replication, there are many more studies on viral-infected sites. Hal-pern et al. Found replicative intermediates of Duck Hepatitis B virus (DHBV) DNA, polyadenylated DHBV RNA and viral antigens, in the pancreas and kidney infected with duck. The existence of replication intermediates suggests that DNA is not caused by blood-borne contamination but rather by intracellular reactive replication. Polygamy