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[目的]比较直接阴道镜检查与HPV DNA检测分流后再行阴道镜检查在处理意义未明的不典型鳞状细胞(ASCUS)患者上的有效性,以探讨ASCUS的处理方案。[方法]将ASCUS患者分为直接阴道镜检查组和HPV检测分流组(高危型HPV DNA阳性者行阴道镜检查),比较两组间的宫颈上皮内瘤变(CIN)2及以上病变检出率。[结果]直接阴道镜检查组CIN2及以上病变的检出率为16.8%,HPV检测分流组CIN2及以上病变的检出率为45.1%,两组间差异有统计学意义(P<0.05)。[结论]在ASCUS患者中,HPV DNA检测分流后再行阴道镜检查较直接阴道镜检查组有更高的CIN2及以上病变检出率。HPV DNA检测分流应作为处理ASCUS患者的首选方案。
[Objective] To compare the effectiveness of direct colposcopy and HPV DNA triage before colposcopy in the treatment of patients with unspecific atypical squamous cell carcinoma (ASCUS) to explore the treatment of ASCUS. [Methods] The patients with ASCUS were divided into direct colposcopy group and HPV test shunt group (high risk HPV DNA positive colposcopy). The cervical intraepithelial neoplasia (CIN) 2 and above lesions were detected between the two groups rate. [Results] The detection rate of CIN2 and above lesions in direct colposcopy group was 16.8%. The detection rate of CIN2 and above lesions in HPV detection shunt group was 45.1%. The difference between the two groups was statistically significant (P <0.05). [Conclusions] In patients with ASCUS, the detection rate of CIN2 and above in colposcopy after HPV DNA test shunt is higher than that of direct colposcopy group. HPV DNA Assay Triage should be the treatment of choice for ASCUS patients.