本文对上海市１６所大、中型医院的部分消化科医生、护士及医护人员１０５０人进行了血清ＨＰ抗体检测，结果提示：１．医务人员，特别是从事消化内镜工作的医生和护士是易受ＨＰ感染的高危人群。揭示ＨＰ通过口－口或粪－口途径传播，医务人员要加强自我防护。２．有消化不良症状者的ＨＰ感染率高于无症状者，提示ＨＰ感染与症状相关。３．家庭密切接触成员中有消化性溃疡病史者的ＨＰ感染率高于无溃疡病史者。 In this paper, serum anti-HP antibody was detected in 1050 of some gastroenterologists, nurses and medical staff in 16 large and medium-sized hospitals in Shanghai. The results showed that: 1. Medical staff, especially those working in digestive endoscopy, are at high risk for HP infection. Revealing that HP is transmitted through the mouth-mouth or fecal-oral route, and medical staff should strengthen their self-protection. 2. Patients with dyspepsia HP infection rate was higher than asymptomatic, suggesting that HP infection and symptoms. 3. HP infection rates among family members with a history of peptic ulcer were higher than those without a history of ulcer.