“恶性综合征”是抗精神病药物引起的一种严重副作用,发生率约为0.5～1％。本征自1960年以来国外文献中即屡有报道,迄今我国已有少数病例见诸文献。本院子1982年遇2例,均因精神分裂症住院,经用抗精神病药物治疗,病情显著好转出院。但均于出院后一周左右发生恶性综合征再次入院, “Malignant syndrome” is a serious side effect caused by antipsychotics, the incidence of about 0.5 to 1%. Intrinsic since 1960 has been repeatedly reported in foreign literature, so far we have seen a small number of cases of literature. In 1982, our hospital encountered 2 cases, both of which were hospitalized for schizophrenia. After being treated with antipsychotics, their condition was significantly improved and discharged. But were discharged again hospitalized about a week after discharge,