论文部分内容阅读
目的 观察严重感染患儿血浆纤维连接蛋白 (Fn)变化及探索抢救治疗的新疗法。方法 设对照组(健康儿 ) 38例 ,观察组 (严重感染儿 ) 77例 ,并在观察组中设伴发绀组与不发绀组。采用免疫透射比浊法分别测定其血浆Fn含量 ,并作对比分析。在伴发绀组又分设输冷沉淀治疗组与非冷沉淀治疗组 ,观察其治疗效果。结果 观察组血浆Fn明显低于对照组 ,差异显著 (P <0 0 1)。伴发绀组Fn又明显低于不伴发绀组 (P <0 0 1)。输冷沉淀组治疗效果明显优于非输冷沉淀组 ,P <0 0 1。结论 严重感染患儿血浆Fn含量明显低于健康儿童。血浆Fn降低的水平与疾病的严重程度有关 ,尤其全身发绀、末梢循环衰竭患儿降低更明显。冷沉淀物可作为血浆Fn的替代疗法以提高抢救成功率。
Objective To observe the changes of plasma fibronectin (Fn) in children with severe infection and explore new therapies for salvage therapy. Methods 38 cases of control group (healthy children), 77 cases of observation group (severe infection), and in the observation group with associated cyanosis group and non-cyanotic group. Immunofluorescence turbidimetry were used to determine the content of Fn in plasma, and compared for analysis. Concomitant cyanosis was divided into transfusion precipitation group and non-cryoprecipitate treatment group, to observe the therapeutic effect. Results The plasma Fn in the observation group was significantly lower than that in the control group (P <0.01). Fn with cyanotic group was significantly lower than those without cyanosis group (P <0.01). The effect of transfusion-cryoprecipitation group was significantly better than non-transfusion-sedimentation group, P <0.01. Conclusion Serum Fn levels in children with severe infection were significantly lower than those in healthy children. Decreased plasma levels of Fn and the severity of the disease, especially systemic cyanosis, peripheral circulatory failure in children with more significant reduction. Cold sediment can be used as an alternative to plasma Fn therapy to improve rescue success rate.