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研究病史资料完整的２６例淋巴瘤患者Ｐ－糖蛋白表达与临床化疗效果的关系。用免疫组织化学ＡＢＣ法检测８４例淋巴瘤初诊患者活检标本中的Ｐ－糖蛋白表达水平。结果：８４例淋巴瘤组织中有１０例Ｐ－糖蛋白表达阳性，阳性率为１１．９％；Ｐ－糖蛋白阳性着色部位主要在细胞浆和细胞膜外侧；阳性细胞多呈片状分布，在阳性和阴性标本中，可见散在分布的阳性细胞。１９例霍奇金病（ＨＤ）中６例呈阳性，６５例非霍奇金淋巴瘤（ＮＨＬ）中Ｐ－糖蛋白阳性有４例。２６例病史资料完整的患者中４例Ｐ－糖蛋白阳性的ＨＤ患者化疗效果较差，３例ＰＲ，１例ＰＤ；４例Ｐ－糖蛋白阴性的ＨＤ患者疗效较好，２例ＣＲ，１例ＰＲ，１例ＮＣ．１８例Ｐ－糖蛋白阴性的ＮＨＬ患者中，疗效为８例ＣＲ，５例ＰＲ，２例ＮＣ，３例ＰＤ，有效率高达７２％。结论：Ｐ－糖蛋白表达阴性的淋巴瘤患者化疗效果较好。
To study the relationship between the expression of P-glycoprotein and the effect of chemotherapy in 26 patients with lymphoma. Immunohistochemical ABC method was used to detect the expression of P-glycoprotein in biopsy specimens of 84 newly diagnosed lymphoma patients. RESULTS: The expression of P-glycoprotein was positive in 10 out of 84 lymphoma tissues, with a positive rate of 11.9%. The positive staining sites of P-glycoprotein were mainly in the cytoplasm and the outer side of the cell membrane; the positive cells were mostly distributed in a sheet form. Positive and negative specimens showed scattered positive cells. Six of 19 cases of Hodgkin’s disease (HD) were positive, and 4 of 65 cases of non-Hodgkin’s lymphoma (NHL) were positive for P-glycoprotein. Among the 26 patients with complete medical history data, 4 patients with P-glycoprotein-positive HD had poorer chemotherapeutic effect, 3 had PR and 1 had PD, 4 had better results with P-glycoprotein-negative HD, and 2 had CR. 1 Case PR, 1 case of NC. In 18 NHL patients with P-glycoprotein negative, the efficacy was 8 CR, 5 PR, 2 NC, and 3 PD, with an effective rate of 72%. Conclusion: The chemotherapy effect of lymphoma with negative P-glycoprotein expression is good.