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Di Guglielmo 综合症是一种较少见的血液疾病,最先是由 Copelli 氏于1912年记载于病理学文献中,1917年意大利学者 Di Guglielmo 首先报告了临床病例,其特点为骨髓内红细胞系统及粒细胞系统同时无限制增生,故名之为红白血病,1923年该氏又报告了一种病例,特点为骨髓内红细胞系统极度增生,伴有不正常的幼红细胞,并有成熟停滞,周围血液中有多量有核红细胞出现,临床上有严重贫血,对 Vit B_(12)治疗无效,名之为红髓病(Eythremic myelosis),并特别强调这是一种独立的疾病。但自
Di Guglielmo syndrome is a rare blood disease, first described by Copelli in the pathology literature in 1912, and in 1917 Italian scholar Di Guglielmo first reported clinical cases characterized by intra-erythroid system and granulocytes Cell system at the same time unlimited proliferation, so named for the red and leukemia, 1923, the disease has reported a case characterized by extreme hyperplasia of bone marrow erythrocyte system, with abnormal erythroblasts, and mature arrest, the surrounding blood There is a large amount of erythroblasts, clinically severe anemia, invalid for Vit B_ (12) treatment, called Eythremic myelosis, with particular emphasis on this is an independent disease. But since