流行病学调查已证实患间皮瘤的危险与石棉接触史有关［１，２］。胸膜腔内注入石棉诱发动物胸膜间皮瘤，可探讨影响间皮瘤发生的因素，如纤维类型及大小、长短等。我们用青石棉和温石棉纤维诱发大鼠胸膜间皮瘤，通过诱发率和生存指标，比较它们的致癌强度。一、材料与方法... Epidemiological investigations have confirmed that the risk of mesothelioma is related to the history of asbestos exposure [1,2]. Injecting asbestos into the pleural cavity induces animal pleural mesothelioma, and factors that influence the occurrence of mesothelioma, such as fiber type, size, and length, can be explored. We induced rat pleural mesothelioma by using crocidolite and chrysotile fiber, and compared their carcinogenicity by the induction rate and survival index. First, materials and methods...