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目的通过对胆固醇结石患者血清瘦素及血脂成分浓度的测定,旨在探讨瘦素(LP)在胆固醇结石形成中的作用。方法收集兰州医学院第二附属医院普外科胆结石住院患者,确定22例作为实验组(胆石组),其中男10例,女12例。术后通过肉眼观察和化学检测证实为胆固醇结石。患者术前进行各项检查排除心、肝、肾等器官病变,且无高血压、糖尿病、肝炎等慢性病变,不伴或伴胆囊炎但非急性发作者。另外,随机抽取本院经体检及生化全项检查无血脂增高及其他明显病变的健康人群16例,其中男8例,女8例,作为对照组。用生化法检测胆固醇结石组患者及对照组血清总胆汁酸(TBA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白的含量;并测身高、体重、腰围,计算体重指数(BMI)、体表面积;用放免法测血清瘦素值。结果胆石组和对照组血脂成分差异具有显著意义。HDL:胆石组为(1.21±0.27)mmol/L,对照组为(1.5±0.3)mmol/L,结石组比对照组低,差异具有显著性意义(t=2.21,P<0.05);血清胆固醇:胆石组为(4.6±0.7)mmol/L,对照组为(4.0±1.0)mmol/L,差异具有显著性意义(t=2.40,P<0.05);载脂蛋白A1(apo-a1):胆石组为(1.28±0.28)g/L,对照组为(1.53±0.25)g/L,差异也具有显著性意义(t=2.56,P<0.05)。胆石组血清瘦素含
Objective To investigate the effect of leptin (LP) in the formation of cholesterol calculus by measuring serum leptin and serum lipid concentrations in patients with cholesterol gallstone. Methods Totally 22 hospitalized patients with gallstone were collected from the Second Affiliated Hospital of Lanzhou Medical College. Twenty-two patients were selected as experimental group (gallstone group), including 10 males and 12 females. Postoperative visual and chemical tests confirmed by the cholesterol stones. Patients preoperative examination exclude heart, liver, kidney and other organ diseases, and no high blood pressure, diabetes, hepatitis and other chronic diseases, without or with cholecystitis but not acute onset. In addition, we randomly selected 16 cases of healthy people who had no blood lipid increase and other obvious pathological changes in our hospital through physical examination and biochemistry examination, including 8 males and 8 females as control group. The serum total bile acid (TBA), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) Protein content; and height, weight, waist circumference, body mass index (BMI), body surface area; using radioimmunoassay serum leptin value. Results Cholesterol group and control group differences in the composition of blood lipid has significant significance. HDL was (1.21 ± 0.27) mmol / L in the gallstone group and (1.5 ± 0.3) mmol / L in the control group, and lower in the stone group than in the control group (t = 2.21, P <0.05) (4.6 ± 0.7) mmol / L in gallstone group and 4.0 ± 1.0 mmol / L in control group (t = 2.40, P <0.05) (1.28 ± 0.28) g / L in gallstone group and (1.53 ± 0.25) g / L in control group. The difference was also significant (t = 2.56, P <0.05). Gallstone group serum leptin containing