关于肥大细胞起源的研究过去一直依靠细胞培养。许多新的实验研究证实结缔组织中的肥大细胞不同于主要存在于胃肠道粘膜的肥大细胞,认为结缔组织的肥大细胞可能来源于单核细胞;粘膜的肥大细胞可能来源于P细胞或粘膜上皮内的淋巴细胞。但是,关于肥大细胞起源迄今尚未明确并且很少有关于人肝组织肥大细胞的报道。本文作者应用针刺活检技术共收集41例急性肝炎患者和5例正常人的肝脏标本。结果5例正常人的标本肥大细胞皆为阴 Research on the origin of mast cells used to rely on cell culture. Many new experimental studies confirm that mast cells in connective tissue are different from mast cells that are predominantly found in the gastrointestinal mucosa and that connective tissue mast cells may be derived from monocytes; mucosal mast cells may be derived from P-cells or mucosal epithelium Within the lymphocytes. However, the origin of mast cells has not been confirmed so far and few reports on human liver tissue mast cells have been reported. The authors applied acupuncture biopsy technique to collect 41 cases of acute hepatitis and 5 normal liver specimens. Results All 5 normal human mast cells were negative