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目的研究慢性肝病患者血清间质胶原酶活性的改变。方法对２０例慢性肝炎、２０例肝硬化患者及３０例正常对照的血清间质胶原酶活性进行了检测；部分病人同时观察了血清ＰＩＩＩＰ、Ｌａｍｉｎｉｎ的变化。结果慢性肝炎及肝硬化组的血清间质胶原酶话性显著低于正常对照组（Ｐ值均＜０．００１）。肝硬化组的血清间质胶原酶活性亦较慢性肝炎组显著为低（Ｐ值＜０．００１）。慢性肝病患者的血清间质胶原酶活性与血清ＰＩＩＩＰ、Ｌａｍｉｎｉｎ均呈显著负相关（分别为Ｐ值＜０．０１和Ｐ值＜０．００１）。结论慢性肝病随着肝组织活动性胶原纤维沉积，血清间质胶原酶活性下降。酶活性下降的原因可能与胶原酶生物合成减少，酶原活化障碍及血中ＴＩＭＰ升高有关。
Objective To study the changes of serum collagenase activity in patients with chronic liver disease. Methods 20 cases of chronic hepatitis, 20 cases of cirrhosis patients and 30 cases of normal control serum interstitial collagenase activity were detected in some patients at the same time observe the changes of serum PIIIP, Laminin. Results The serum levels of serum interstitial collagenase in chronic hepatitis and cirrhosis patients were significantly lower than those in normal controls (P <0.001). Serum interstitial collagenase activity was also significantly lower in patients with cirrhosis than in those with chronic hepatitis (P <0.001). Serum interstitial collagenase activity was significantly negatively correlated with serum PIIIP and Laminin in patients with chronic liver disease (P <0.01 and P <0.001, respectively). Conclusion With the deposition of active collagen fibers in liver tissues, the activity of collagenase in serum is decreased. Decrease in enzyme activity may be due to reduced collagenase biosynthesis, zymogen activation disorders and elevated blood levels of TIMP.