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目的:分析使用肿瘤表面刮片技术检测头颈部肿瘤患者人乳头状瘤病毒(HPV)感染结果。方法:2010年1月至2011年6月间,在我院头颈放疗科就诊的经病理证实的头颈部肿瘤患者139例,采用肿瘤表面刮片第二代杂交捕获试验(HC-Ⅱ)技术分析测定HPV感染。结果:139例头颈部肿瘤患者中口咽癌及下咽癌22例,鼻咽癌107例,口腔癌2例,喉癌2例,其他恶性肿瘤6例。139例头颈部肿瘤组织中HPV感染共14例,感染率为10.1%。口咽及下咽癌、鼻咽癌患者HPV感染分别为5例(22.7%)、8例(7.5%)。HPV感染者中HPV-16型感染占44%。结论:头颈部肿瘤使用肿瘤表面刮片第二代杂交捕获试验(HC-Ⅱ)技术进行HPV检测有可行性,HPV感染可能是咽部肿瘤特别是口咽癌的重要致病因素之一。HPV感染与鼻咽癌致病原因的关系有待进一步确认。
OBJECTIVE: To analyze the results of human papillomavirus (HPV) infection in patients with head and neck cancer using tumor surface scraping technique. Methods: From January 2010 to June 2011, 139 patients with pathologically proven head and neck cancer were treated by Head and Neck Radiotherapy in our hospital. The second generation hybridization capture test (HC-Ⅱ) Analysis of HPV infection. Results: Among 139 patients with head and neck cancer, there were 22 cases of oropharyngeal and hypopharyngeal cancer, 107 cases of nasopharyngeal carcinoma, 2 cases of oral cavity cancer, 2 cases of laryngeal cancer and 6 cases of other malignant tumors. There were 14 cases of HPV infection in 139 cases of head and neck cancer tissues, the infection rate was 10.1%. Oropharyngeal and hypopharyngeal cancer, HPV infection in patients with nasopharyngeal carcinoma were 5 cases (22.7%), 8 cases (7.5%). HPV-16 infection in HPV-infected 44%. CONCLUSIONS: HC-Ⅱ detection is feasible for head and neck cancer using the second generation hybridization capture assay (HC-Ⅱ). HPV infection may be one of the important risk factors for pharyngeal tumors, especially oropharyngeal cancer. HPV infection and the pathogenesis of nasopharyngeal cancer needs further confirmation.