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目的研究鼻腔小圆细胞性恶性黑色素瘤临床病理特征及其鉴别诊断。方法收集12例鼻腔小圆细胞性恶性黑色素瘤,通过组织学和免疫组化进行观察。结果鼻腔小圆细胞性恶性黑色素瘤细胞呈弥漫、片状或巢状分布,瘤细胞形态较为一致,瘤细胞小、圆形、胞质稀少,无色素。大部分病例肿瘤细胞围绕小血管呈血管外皮瘤样排列。免疫组化vimentin、S-100、HMB45和melan-A为(+)。结论鼻腔小圆细胞性恶性黑色素瘤罕见,需要通过组织学和免疫组化染色特点作出正确的诊断,并同鼻腔其他小圆细胞性恶性肿瘤鉴别。
Objective To study the clinicopathological features and differential diagnosis of nasal small cell malignant melanoma. Methods 12 cases of nasal small cell malignant melanoma were collected and observed by histology and immunohistochemistry. Results Nasal small round cell malignant melanoma cells were diffuse, flaky or nested distribution, tumor cells more consistent morphology, tumor cells small, round, sparse cytoplasm, no pigment. Most cases of tumor cells around the small blood vessels showed hemangioperitoneal-like arrangement. Immunohistochemistry of vimentin, S-100, HMB45 and melan-A was (+). Conclusion Nasal small cell malignant melanoma is rare and needs to be correctly diagnosed by histological and immunohistochemical staining and differentiated from other small cystic malignancies in the nasal cavity.