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经口给予小鼠幽门螺杆菌 (HP)抗原疫苗 2周后 ,提取脾淋巴细胞和胃粘膜固有层 T淋巴细胞(L PL) ,检测细胞毒活性和 IL- 2诱生能力的改变。结果显示 HP抗原疫苗能增强胃 L PL 细胞毒活性和 IL-2的分泌量。对脾淋巴细胞的细胞毒活性影响不大 ,IL- 2诱生能力稍有下降。证实 HP抗原疫苗对胃粘膜固有层 T淋巴细胞有免疫激活作用
Two weeks after oral administration of the HP antigen vaccine, T lymphocytes (LPL) of spleen lymphocytes and lamina propria of gastric mucosa were extracted and tested for cytotoxicity and IL-2 inducing ability. The results showed that HP antigen vaccine can enhance gastric LPL cytotoxic activity and IL-2 secretion. Little effect on the cytotoxic activity of splenic lymphocytes, IL-2 induced ability decreased slightly. Confirmed HP antigen vaccine on gastric mucosal lamina propria T lymphocytes immune activation