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通过实验首次发现了2,6-二羟基-3-氰基-4-三氟甲基吡啶氯代反应中两个羟基的单氯代产物,在理论上分析了两个羟基的反应活性不同,确定了参与氯代反应的羟基的位置。通过核磁谱图进行了结构鉴定。并经优化反应条件可选择性只生成单氯代目的产物,简化了合成步骤,提高了反应收率。
Through the experiment, we found for the first time that the monochloro-substituted products of two hydroxyl groups in the 2,6-dihydroxy-3-cyano-4-trifluoromethylpyridine chlorination reaction were theoretically analyzed. The reactivity of the two hydroxyl groups was different, The position of the hydroxyl group involved in the chlorination reaction was confirmed. Structural identification was carried out by nuclear magnetic resonance spectroscopy. And the optimized reaction conditions can selectively produce only the target product of monochlorination, simplifying the synthesis steps and improving the yield of the reaction.