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作者应用ＡＢＣ免疫组化法研究４０例胆囊癌和５例正常胆囊粘膜标本中突变型Ｐ５３蛋白的表达及其意义。结果显示胆囊癌中突变型Ｐ５３蛋白表达阳性率为５０％，正常胆囊粘膜全部为阴性。突变型Ｐ５３蛋白的表达阳性率在不同的病理分级、淋巴结是否转移及预后患者间差异显著（Ｐ＜０．０１）。在Ｎｅｖｉｎ分期间未测出显著相关性（Ｐ＞０．０５）。结果提示突变型Ｐ５３基因参与了胆囊肿瘤的恶性转化过程，其表达阳性率高的胆囊癌预后不良，是反应胆囊癌生物学行为和预后的重要指标。
The authors applied ABC immunohistochemistry to study the expression and significance of mutant P53 protein in 40 cases of gallbladder carcinoma and 5 cases of normal gallbladder mucosa. The results showed that the positive expression rate of mutant P53 protein in gallbladder carcinoma was 50%, and all normal gallbladder mucosa were negative. The positive rate of mutant P53 protein was significantly different among patients with different pathological grades, lymph node metastasis, and prognosis (P<0.01). No significant correlation was detected during the Nevin fraction (P>0.05). The results suggest that the mutant P53 gene is involved in the malignant transformation of gallbladder tumors. The positive expression rate of gallbladder carcinoma with a high positive rate is an unfavorable prognosis. It is an important indicator to reflect the biological behavior and prognosis of gallbladder carcinoma.