载脂蛋白分10O家族性缺陷是一种常染色什显性遗传病，多伴发高胆固醇血症。作者对在Scot－land及Wales脂质诊所的357例高胆固醇血症患者中的48例临床诊断为家族性高胆固因血症患者进行APOB－100家族缺陷症筛检。发现7例不相关患者中5例有冠。心病家族史；另11例为第一系亲属的 Apolipoprotein 10O familial defect is an autosomal dominant dominant disease, often accompanied by hypercholesterolemia. The authors screened APOB-100 familial deficiencies in 48 clinically diagnosed patients with familial hypercholesterolemia in 357 hypercholesterolemic patients at the Scot-land and Wales Lipids Clinic. Five of the seven unrelated patients were found to have crowns. Family history of heart disease; the other 11 cases of first-mover