由于体内外因素的影响,DNA损伤是生物生命周期中的常见现象,如果得不到及时的修复,DNA损伤的积累将导致基因组的不稳定及染色质的异常,并可能导致肿瘤的发生发展。SUMO化修饰是体内一个重要的蛋白质翻译后修饰,越来越多的研究发现SUMO化修饰与多个参与DNA损伤反应、维持基因组稳定的蛋白质相关,有可能参与肿瘤的发生。本文将阐述SUMO化修饰与DNA损伤修复的关系。 DNA damage is a common phenomenon in the biological life cycle due to the influence of internal and external factors. If not repaired in time, the accumulation of DNA damage will lead to genomic instability and chromatin abnormalities, and may lead to tumor development. SUMOylation is an important post-translational modification of protein in vivo. More and more studies have found that SUMOylation may be involved in many oncogenes involved in the DNA damage response and maintenance of genome stability. This article will explain the relationship between SUMOylation and DNA damage repair.