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目的:探讨hMSH2蛋白在喉鳞状细胞癌组织中的表达及意义。方法:采用免疫组织化学法检测喉鳞状细胞癌组织中hMSH2蛋白的表达,并以声带不典型增生组织和正常喉组织作为对照。结果:在喉鳞状细胞癌、声带不典型增生组织和正常喉组织中hMSH2蛋白的阳性率依次为58.8%、73.3%、87.5%,各组间差异有统计学意义(P<0.05);hMSH2蛋白的阳性率与喉癌部位、T分期无明显相关性(P>0.05),而与喉癌的分化程度、淋巴结转移具有相关性(P<0.05)。结论:hMSH2蛋白表达下调可能参与了喉癌早期的发生过程;hMSH2蛋白可能具有抑制喉癌发生发展的作用。
Objective: To investigate the expression of hMSH2 protein in laryngeal squamous cell carcinoma and its significance. Methods: The expression of hMSH2 protein in laryngeal squamous cell carcinoma was detected by immunohistochemistry. The vocal cord dysplasia and normal laryngeal tissues were used as control. Results: The positive rates of hMSH2 protein in laryngeal squamous cell carcinoma, vocal cord atypical hyperplasia and normal laryngeal tissues were 58.8%, 73.3% and 87.5%, respectively, with significant difference (P <0.05); hMSH2 The positive rate of protein was not correlated with the location and T stage of laryngeal carcinoma (P> 0.05), but correlated with the degree of differentiation and lymph node metastasis (P <0.05). Conclusion: The down-regulation of hMSH2 protein may play an important role in the early development of laryngeal carcinoma. The hMSH2 protein may inhibit the development of laryngeal carcinoma.