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目的:制备溴新斯的明多囊脂质体(NB-MVL),并对其体外药物释放行为进行考察。方法:采用复乳法制备载药多囊脂质体,并用单因素试验优化处方,以动态透析技术与f2相似因子评价法对NB-MVL与溴新斯的明在体外不同释放介质中的释放行为进行研究,计算其药物释放度与相似因子。结果:NB-MVL的包封率受投料比、药物浓度等因素影响;NB-MVL在不同的释放介质中所获得的释放模型均符合Weibull模型,同时与溴新斯的明溶液在不同释放介质中所得累积释放曲线间的相似因子小于50。结论:本试验制备所得NB-MVL包封率较高,且体外药物释放行为与溴新斯的明存在显著性差异,表现出良好的缓释作用。
OBJECTIVE: To prepare bromovanostine liposomes (NB-MVL) and investigate its in vitro drug release. Methods: Multi-capsulated liposomes were prepared by double-emulsion method. The single-factor experiments were used to optimize the formulation. The dynamic dialysis technique and the f2 similarity factor method were used to determine the release of NB-MVL and bromine neostigmine in different release media in vitro Conduct research to calculate the drug release and similar factors. Results: The entrapment efficiency of NB-MVL was affected by factors such as the feed ratio and drug concentration. The release models of NB-MVL in different release media were in accordance with the Weibull model, and the release of NB-MVL in different release media The similarities between the cumulative release curves obtained were less than 50. Conclusion: The encapsulation efficiency of NB-MVL obtained in this study is high, and there is a significant difference between in vitro drug release behavior and bromine neostigmine, showing good sustained release effect.