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目的 观察乐舒痰对小儿急性下呼吸道感染的祛痰效果以及量化咳嗽、峰流值 (PEF)作为疗效观察指标的可行性。方法 将 10 6例急性下呼吸道感染的患儿随机分为治疗组 5 5例和对照组 5 1例 ,并设计了量化咳嗽和 PEF等观察指标。结果 两组患儿的综合疗效无明显差异 (P>0 .0 5 ) ,但乐舒痰组患儿的咳嗽、肺部干性罗音及 PEF恢复正常的时间明显短于对照组 ((P<0 .0 5 )。同时还显示 ,量化咳嗽和 PEF能更早地反映上述统计学上的差异。结论 1乐舒痰是一种安全有效的祛痰剂 ;2量化咳嗽和 PEF是开展祛痰药物对小儿祛痰作用研究的两个客观而实用的指标。
Objective To observe the expectorant effect of Le Shu sputum on acute lower respiratory tract infection in children and to evaluate the feasibility of quantifying cough and peak flow (PEF) as an index of curative effect. Methods A total of 106 children with acute lower respiratory tract infection were randomly divided into treatment group (n = 55) and control group (n = 51). Quantitative cough and PEF indexes were also designed. Results There was no significant difference between the two groups (P> 0.05), but the duration of cough, pulmonary rales and PEF returned to normal was significantly shorter in the Yue Shu Sputum group than in the control group (P <0 .0 5) .It also showed that the quantitative cough and PEF can reflect the above statistical differences earlier.Conclusion1 Le Shu sputum is a safe and effective expectorant; 2 to quantify cough and PEF is to carry out Phlegm drugs on children expectorant effect of two objective and practical indicators.