难治性肾病综合征(NS)是医学上棘手的问题,虽然环磷酰胺(CTX)、环孢素A(CSA)治疗可能取得部分疗效,但因其副作用受到限制。我们观察新型免疫抑制剂骁悉联合肝素抗凝治疗NS的临床效果,现报告如下。1　材料与方法1 1　治疗对象　15例患者均符合原发性NS的诊断标准,其中女性9例,男 Refractory nephrotic syndrome (NS) is a medically challenging problem. Although cyclophosphamide (CTX) and cyclosporin A (CSA) may have partial efficacy, their side effects are limited. We observe the new immunosuppressive agents combined with heparin anticoagulant therapy in the clinical effect of NS, are as follows. 1 Materials and Methods 1 1 treatment of 15 patients were in line with the diagnostic criteria of primary NS, including 9 females, male