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胃癌的发生是一个多因素、多步骤的复杂过程,环境因素与遗传因素的相互作用决定了这一过程的发展和结局。幽门螺杆菌(H.pylori)感染和宿主本身胃癌遗传易感性基因的多态性被认为是胃癌的重要危险因素。本文就H.pylori感染及IL-4、PTPN-11基因多态性与胃癌发生、发展相关性研究进展作一综述。
The occurrence of gastric cancer is a complex and multi-step process. The interaction between environmental and genetic factors determines the development and outcome of this process. Polymorphism of H. pylori infection and genetic susceptibility to gastric cancer in the host itself is considered as an important risk factor for gastric cancer. This article reviews the research progress of the correlation between H.pylori infection, IL-4, PTPN-11 gene polymorphisms and the occurrence and development of gastric cancer.