急性肺损伤可见于休克、严重创伤、烧伤、感染、吸入有毒气体等,其发生机理尚不清楚。近来发现多形核中性粒细胞(PMN)在其中起着重要作用。多种损伤因子可直接或通过旁路活化补体系统产生C5a,和刺激肺泡巨噬细胞(AM)释放另一种小分子趋化因子,诱导大量PMN在肺内聚集、活化、并至少释放三组参与肺损伤的 Acute lung injury can be seen in shock, severe trauma, burns, infections, inhalation of toxic gases, the mechanism is not yet clear. Recently, polymorphonuclear neutrophils (PMNs) have been found to play an important role. A variety of damaging factors can produce C5a either directly or via a bypass activated complement system and stimulate the release of another small molecule chemokine by alveolar macrophages (AM), inducing a large number of PMNs to aggregate and activate in the lungs and release at least three Involved in lung injury