对通过抑制细菌细胞内蛋白质或核酸合成而抗菌的药物,特别是氨基糖甙类,在MIC以上的浓度对多种革兰阴性细菌等作用后,与药物脱离接触一段时间内,仍保持有抗生素后效作用,使该类药物的给药方法发生了根本的改变。对氨基糖甙类,一日一次给药的疗效等同于或优于一日多次给药,这就为临床正确使用该类药提出了新的要求。 Antibiotics, especially aminoglycosides, that inhibit bacterial cell proteins or nucleic acid synthesis, remain active until they are exposed to a wide range of Gram-negative bacteria at concentrations above the MIC for some time After effects, so that the drug administration methods have undergone fundamental changes. For aminoglycosides, the effect of once-a-day administration is equal to or better than multiple administrations on the 1st day, which sets new requirements for the clinical use of such drugs.